Saudi Pharmacist Licensing Exam Questions

Saudi Prometric SPLE exam preparation MCQs
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26) A 25-years-old male is admitted to a hospital due to a hypersensitivity reaction to some drug ingested some three hours ago. The patient is given a drug that causes dilatation of vessels in muscle, constriction of cutaneous vessels, and positive inotropic and chronotropic effects on the cardiac tissue.

Which of the following is the most likely drug given? 

A)Adrenaline

B)Isoproterenol

C)Acetylcholine

D)Metaproterenol

E) Atropine



27) Following is the data of heights in cm of 13 pediatric patients :

90, 9, 103, 107 ,110 ,124 ,129, 131 ,136 ,140 ,142 ,145 ,150

Measuring the central tendency, what does the value '129' represent?

A)Mode

B)Mean 

C)Median

D)Confidence interval

E) Average



28) The pharmacological effects of four antihypertensive drug classes (A-D) on the renin-angiotensin system are shown in the following table;

ParametersDrug-ADrug-BDrug-CDrug-D
Renin-Conc.🠋🠉🠉🠉
Angiotensin-I-Conc.🠋🠉🠉🠉
Angiotensin-II-Conc.🠋🠋🠉🠉
Angiotensin-Receptor------🠋---

Which class is represented by the drug -D?

A Diuretics
B Direct Renin inhibitors
C Angiotensin II receptor blockers
D Angiotensin-converting enzyme inhibitor
E) Adrenergic agents




29) The mode of transmission refers to how an infectious agent can be transferred from one person to another. Which among the following describes the mode of transmission of coronavirus?
A) by consuming contaminated foods and drinks
B) through blood transfusion
C) fomite transmission
D) by coming in contact with the patient's saliva
E) through the respiratory route



30) Eukaryotic cells contain highly abundant, small nuclear-bound non-coding RNAs that are specifically called snRNAs or small nuclear RNAs. The function of these snRNAs molecules in protein synthesis is;
A) Genetic blueprint for the protein
B) Modifies mRNA molecules
C) Assembly of amino acids
D) Translates genetic code to amino acid
E) Act is a catalyst




31) The primary reaction of our bodies to a foreign harmful substance is innate immunity. Identify the component that is not part of the innate immune system?
A) respiratory tract
B) eyelashes 
C) gastrointestinal tract
D) inflammatory response
E) all of the above are parts of the innate immune system




32) Which immune system cells produce and release histamine as part of the immune response to pathogenic intruders?
A) Dendritic cells
B) Mast Cells
C) Basophils 
D) Neutrophils 
E) Both B and C




33) A pediatric patient has been diagnosed with a kind of blood cancer called Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) and has been prescribed an imatinib 400mg daily regimen. Which information is incorrect regarding the dosing and administration of this anti-cancerous agent?
a- should be taken with a meal to prevent stomach upset
b- the 400mg daily dose should be administered in divided doses
c- can be dissolved in water or apple juice before taking
d- administration with iron supplements should be avoided
e- during therapy sun exposure should be minimized




34) There are many types of medication errors possible in a healthcare setting, some are easily preventable while others are difficult to prevent. Which of the following medication errors is difficult to prevent?
A) Dispensing an incorrect medication, dosage strength, or dosage form
B ) Omission error
C) Wrong time error
D) Incorrect duration of treatment 
E) Allergic reactions to a medication




35) Which of the following best describes the structure of the healthcare systems in Saudi Arabia?
A) private healthcare system
B) public healthcare system
C) 2-tier system
D) 3-tier system
E) 4-tier system






36) A 69-year-old lady presented with a complaint of severe dry cough for a week. She has recently been prescribed the following medications;
-- hydrochlorothiazide and captopril for hypertension, 
-- sitagliptin and metformin to manage her high blood sugar, 
-- salbutamol and fexofenadine for allergic asthma.
Which drug is the most likely cause of the patient’s complaint? 
A) Fexofenadine
B) Sitagliptin
C) Captopril
D) Salbutamol
E) Hydrochlorothiazide




37) As part of the survey of pharmacy staff, which one of the following best describes pharmacy health literacy assessment? 
A) Measure how well the pharmacy is serving patients with limited health literacy skills
B) Discover gaps in the written information provided to served patients
C) Measuring how well the pharmacy staff is health literate
D) Explore understanding of health care information by the illiterate
E) Assess the level of literacy in the served patients




38) In a gynecological scenario, which of the following agents can be employed to cope with labor pain?
a- ropivacaine
b- oxymorphone
c- pentazocine
d- butorphanol
e- all of the above




39) The following drug(s) can suppress lactation for women who do not want to breastfeed their babies;
a- clomiphene
b- bromocriptine
c- ergot derivatives
d- androgens
e- all the mentioned agents




40) A 26-year-old man encounters a serious road crash. He is brought to the hospital with deep wounds. His vaccination history is unknown. Which of the following would be best to administer to this patient at this time?
A)Tetanus toxoid
B)Tetanus vaccine
C)Tetanus immunoglobulin 
D)Tetanus vaccine and tetanus immunoglobulin
E)Tetanus vaccine and human papillomavirus vaccine




41) Which agent among the following can be prescribed to women who want to breastfeed their babies?
a- levodopa
b- metoclopramide
c- bromocriptine
d- tamoxifen
e- ergotamine




42) The complement system part of the innate immune system can be activated by which of the following immunoglobulins?
A) IgM
B) IgE
C) IgA 
D) IgG
E) Both A and D






43) The antibacterial agent Amoxicillin has been classified under category B according to the FDA categories of drug safety during pregnancy. This means what?
A) No satisfactory animal or human studies have been conducted
B) Controlled human studies show no fetal risks from amoxicillin exposure
C) Evidence of human fetal risk exists, but the benefits may outweigh the risks
D) No proper pregnant women studies but animal studies show a risk to the fetus
E) No risk to the fetus in animal studies but no adequate humans studies




44) Which of the following is the function of the pharmacy and therapeutics (P&T) committee in a hospital setting?
A) Responsible for poison cases management
B) Educating the medical staff regarding patient treatment
C) Monitor the medication error reporting 
D) Responsible for drug formulary management
E) Monitor the adverse drug reactions reporting




45) Glycogen which is the storage form of glucose in our bodies, its breakdown process is referred to as ____________ in the literature.
A) Respiration
B) Glycogenesis 
C) Glycogenolysis
D) Gluconeogenesis
E) Glycolysis




46) Before the research initiation, investigators must submit all the relevant research protocols to the administrative body of IRB or Institutional Review Board for review and obtain its approval. What is the main responsibility of this board?
A) to facilitate the smooth conduction of research
B) to provide the needed funds for the research 
C) to protect the rights, welfare, and privacy of human research subjects
D) to decide about the most appropriate sample size for the research
E) to help in collecting the research data




47) Patients living with chronic conditions can be helped with their medication adherence through an in-home electronic medication dispensing system which research has shown to be effective for achieving better results. Which of the following can be used for this purpose?
A) Text messaging
B) Cell phone calendar
C) e-pill Multi Alarm TimeCap 
D) Med-E-Lert Automatic Pill Dispenser
E) ScriptPro machine




48) In regard to managing geriatrics patients, which of the following strategies can be used to encourage them for changing their behavior? 
A) Use teach-back more often throughout the session
B) Introduce new concepts more slowly
C) Use briefer educational sessions
D) Express explicitly the adverse health outcomes in case they do not take their medications
E) Use more visual aids, gestures, yes/no responses, and facial expressions




49) Alcohol dehydrogenase is an enzyme that is found primarily in the liver and stomach. Which of the following best describes its function?
A) accelerates the reduction of ethanol
B) accelerate the addition of hydrogen to ethanol
C) accelerates the addition of phosphate to ethanol
D) accelerates the removal of hydrogen from ethanol
E) accelerates the conversion of ethanol into carbon dioxide and water






50) Nitrogenous bases in DNA are grouped into two categories: purines and pyrimidines. Which of the following pairs represents the pyrimidine nitrogenous bases?
A) Adenine and Uracil
B) Guanine and Uracil
C) Adenine and Guanine
D) Cytosine and Guanine
E) Cytosine and Thymine




-----------  Continued...


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