Saudi Pharmacist Licensing Exam Questions

Saudi Prometric SPLE exam preparation MCQs
www.pharmacymcqs.com

126) Which type of tablet is designed to delay the release of the active ingredient until it reaches the intestine?
a) Chewable tablets
b) Enteric-coated tablets
c) Sugar-coated tablets
d) Effervescent tablets
e) Troches





127) Which of the following conditions is Troches commonly used to treat?
a) Diabetes
b) Hypertension
c) Oral thrush
d) Asthma
e) Morning sickness





128) PGP or P-glycoprotein is a drug transport protein. The 'P' in P-glycoprotein stands for;
a- peripheral
b- permeability
c- phosphatized
d- power-dependent
e- power-independent





129) Among the following medications, which one is most likely to show a significant increase in blood levels with even small changes in dose?
A. Sodium valproate
B. Carbamazepine
C. Digoxin
D. Warfarin
E. Phenytoin





130) What is the purpose of using occlusive dressings with topical corticosteroids in clinical practice?
A. To decrease the risk of skin atrophy
B. To reduce the penetration of the steroid into the dermis
C. To promote the absorption of the steroid systemically
D. To decrease the likelihood of bacterial skin infections
E. To enhance the penetration of the steroid into the dermis




131) Sublingual tablets are tablets that are designed to be;
a) placed under the tongue and allowed to dissolve
b) inserted into the vagina
c) inserted into the rectum
d) chewed and swallowed
e) dissolved in water and injected into the body





132) Which statement regarding drug absorption is correct?
A. A drug is not absorbed unless its pKa is high.
B. A drug is absorbed only after it is dissolved in a solution.
C. A drug is not absorbed until it is metabolized.
D. Optimal surface area is required for drug absorption.
E. A drug is absorbed only after it has reached the colon.





133) Which of the following statements about cationic aqueous creams is INCORRECT?
A. They contain cationic surfactants as part of their primary emulsifying system
B. They contain anionic surfactants as part of their primary emulsifying system
C. Cationic aqueous creams are compatible with cations
D. The stability of the emulsion increases when mixed with cationic preparations
E. The activity of the drug increases when mixed with cationic preparations





134) Which of the following terms refers to a system made up of a liquid dispersed in another liquid?
A. Foam
B. Gel
C. Suspension
D. Aerosol
E. Emulsion





135) Which of the following statements accurately describes a drug with a very small volume of distribution (Vd)?
A. The drug has a low potency
B. The drug is eliminated from the body quickly
C. The drug does not accumulate in various tissues and organs
D. The drug has a high therapeutic index
E. The drug is widely distributed in the body





136) What is the recommended way to take Troches?
a) Swallow the Troche whole with water
b) Chew the Troche and swallow it
c) Let the Troche dissolve slowly in the mouth
d) Crush the Troche and mix it with water
e) Take it with a full glass of milk





137) Which one of the following medications does not undergo systemic absorption after oral administration?
A. Nystatin
B. Trimethoprim
C. Cephalexin
D. Oxytetracycline
E. Rifampicin





138) Which of the following routes of drug administration results in the MOST rapid onset of pharmacological effect?
A. Intramuscular
B. Oral 
C. Subcutaneous
D. Sublingual
E. Rectal 





139) Which of the following bacterial genera is most commonly associated with acne vulgaris?
A. Escherichia
B. Staphylococcus
C. Streptococcus
D. Propionibacterium
E. Clostridium





140) Which of the following is the reason for thiopentone having a shorter duration of action than phenobarbitone?
A. Slow absorption from the stomach
B. Higher solubility in water
C. Rapid metabolism by the liver.
D. Rapid excretion by the kidneys.
E. Higher lipid solubility





141) The pharmaceutical dosage form 'troches' is also known as:
a) Lozenges
b) Effervescent tablets
c) Dispersible tablets
d) Sustained-release tablets
e) Sublingual tablets





142) The type of injection for which a suspension is NOT an appropriate dosage form?
A. Intramuscular
B. Subcutaneous
C. Intra-articular
D. Intradermal
E. Intravenous





143) Which of the following microorganisms is not susceptible to treatment with clindamycin?
A. Clostridium difficile
B. Bacteroides species
C. Fusobacterium species
D. Clostridium perfringens
E. Bacteroides fragilis





144) Which of the following is NOT an official pharmacopeial testing procedure for tablets?
A. Dissolution testing
B. Content uniformity testing
C. Friability testing
D. Disintegration testing
E. Hardness testing





145) Which of the following is a common ingredient in Troches?
a) Sodium chloride
b) Calcium carbonate
c) Lactose
d) Sucrose
e) Fructose





146) What drug has the longest half-life among the following options?
a- Fentanyl
b- Amlodipine
c- Verapamil
d- Theophylline
e- Morphine





147) The drug that is not administered as a racemic mixture is:
A. Warfarin
B. Esomeprazole
C. Verapamil
D. Ibuprofen
E. Propoxyphene





148) Which is the most appropriate method for determining the bioequivalence of two tablets that contain the same amount of a drug made by different companies?
A. Measuring the serum concentrations of the drug after ingestion
B. Measuring the dissolution times of the tablets
C. Measuring the disintegration times of the tablets
D. Measuring the drug content of each tablet
E. Measuring the rate at which each drug is excreted





149) Which factor determines the time required to achieve a steady-state plasma level when a fixed dose of a drug eliminated by first-order kinetics is given intravenously at regular intervals?
A. The elimination half-life of the drug.
B. The bioavailability of the drug
C. The given dose of the drug
D. The dosing interval
E. The volume of distribution of the drug.





150) Which type of tablet is designed to dissolve slowly in the mouth?
a) Dispersible tablets
b) Hypodermic tablets
c) Sustained-release tablets
d) Troches
e) Implant tablets






----------- Continued

--------------------------------------------------------------------------- 

Answer Keys

MCQ # - Correct option

126- b

127- c

128- b

129- e

130- e

131- a

132- b

133- b

134- e

135- c

136- c

137- a

138- d

139- d

140- e

141- a

142- e

143- a

144- e

145- d

146- b

147- b

148- a

149- a

150- d


WATCH ALSO: 👇👇👇👇👇

www.pharmacymcqs.com